Leo Pharma Anabolics Dianabol 10 Mg Tablet Exporter From New Delhi
Below is a concise "reference‑style" summary of the six molecules you listed. It is intended solely as an information resource; none of these chemicals have been approved for therapeutic use by major regulatory agencies (FDA, EMA, etc.). If any of them are considered for research or clinical work, they must be handled under appropriate institutional and legal guidelines, and any human exposure should be supervised by qualified professionals.
| # | Molecule (chemical name) | Key Structural Features | Known Biological Activity / Target(s) | Notes on Research Status | |---|--------------------------|-------------------------|--------------------------------------|---------------------------| | 1 | **N,N′‑bis(3‑(trifluoromethyl)phenyl)-2‑hydroxy‑4,5,6,7‑tetrafluoro‑1H‑pyrazolo1,5‑apyrimidine** | - Pyrazolopyrimidine core - Two CF₃‑substituted phenyl rings (electron‑withdrawing) - Hydroxyl at position 2 and multiple fluorines (high lipophilicity) | Potential kinase or GPCR inhibitor; electron‑rich heterocycle may bind ATP‑binding sites; strong hydrophobic interactions due to CF₃ groups. | High metabolic stability from fluorination; however, bulky CF₃ groups could hinder permeability. | | **2** | 4-(3-(4-Methyl-1-piperazinyl)-5-methylpyridin-4-yl)benzenesulfonamide | – Sulfonamide core (H‑bond acceptor/donor) – Piperazine ring (basic, protonated at physiological pH) – Pyridine + methyl groups (lipophilic) – Phenyl ring (aromatic hydrophobic) | **Lipophilicity**: moderate (phenyl + pyridyl). **H‑bonding**: sulfonamide NH can donate; O atoms accept. **Basicity**: piperazine N protonated → positive charge, improving solubility but reducing passive permeability. **Metabolic sites**: aromatic methyls, phenyl ring (possible oxidation), and the piperazine ring (N-dealkylation). | 1) **Methyl‑to‑hydroxyl oxidation** on pyridyl ring → introduce polar OH. 2) **Hydrolysis of sulfonamide** to amide + H₂O or direct N‑dealkylation on piperazine. | | 3 | **Compound C:** `CC(=O)c1ccc(-c2nnn(CC(=O)NCCCN(C)C)c2)c(Cl)c1`
Structure: an acetylated, chlorinated phenyl ring bearing a triazole‑linked side chain (pyrrolidine–derived). The side chain contains two amide bonds and a tertiary dimethylamine. | **Key features:** • Aromatic ring with Cl, Acetyl substituent – increases lipophilicity but also metabolic stability. • Triazole heterocycle – polar, can serve as H‑bond acceptor. • Two amide linkages – sites for hydrolysis; increase polarity. • Terminal tertiary dimethylamine – basic, raises pKa, influences solubility and ionization. | **Predicted behavior:** The compound has a relatively balanced profile: aromatic hydrophobic core plus polar amide/amine groups. It is likely to be more soluble than the purely non‑polar analogues but less so than the highly lipophilic phenyl ether. The presence of two amides may lead to moderate metabolic degradation; however, the overall structure should remain reasonably stable in vitro.
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## 3. Ranking by Solubility (Descending Order)
| Rank | Compound | Reasoning | |------|----------|-----------| | **1** | Phenyl‑methoxy‑naphthalene (Phenyl‑Methoxy) | Contains a methoxy group that introduces polarity; the overall structure is still relatively hydrophobic, but the heteroatom increases solubility compared to fully non‑polar analogues. | | **2** | 4‑(1H‑Indol‑3‑yl)-phenyl‑methoxy | Indole nitrogen provides additional H‑bonding ability; however, the indole ring also contributes hydrophobic surface area. | | **3** | Naphthalene‑methoxy‑naphthalene (Naphthalene‑Methoxy) | The central methoxy offers polarity but is surrounded by two large hydrophobic naphthalene rings, resulting in lower solubility than the phenyl‑based analogues. |
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### Key Takeaway
- **Polarity and H‑bonding sites** dominate solubility trends: molecules with more heteroatoms (O/N) and fewer aromatic rings are generally more soluble in aqueous environments. - **Increasing aromatic ring count** or introducing additional hydrophobic groups tends to reduce solubility, despite any polar substituents.
This simplified view should help you predict which of your synthesized compounds will be more amenable to aqueous formulation. Feel free to reach out if you'd like a deeper dive into specific physicochemical properties or solubility calculations!
